Error Deleting file or Folder help!!?!?!?@?

When i try to delete 2 folders that are empty it says Cannot delete file: Cannot read from thes source file or disc, well i tried deleting it in safe mode it said the same thing and in that file there was once a video then i moved the vid out of the file then i tried deleting it, it said errir deleting file or folder and i know when it says that its being used by a nother program but it isnt i even tried it in safe mode can you help??? please????????